Asian Journal of Case Reports in Medicine and Health

A Successful Treatment of a Patient Infected with Pan-drug Resistant Acinetobacter baumannii Ventriculitis with Intravenous Sulbactam: A Case Study

P. Keandoungchun *

Department of Internal Medicine, Prasat Neurological Institute, Bangkok, Thailand.

P. Narischat

Department of Neurosurgery, Prasat Neurological Institute, Bangkok, Thailand.

W. Laosuebsakhunthai

Department of Pharmacy, Prasat Neurological Institute, Bangkok, Thailand.

A. Ubontachart

Neurosurgical Intensive Care Unit, Prasat Neurological Institute, Bangkok, Thailand.

*Author to whom correspondence should be addressed.

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Abstract

The post neurosurgical ventriculitis caused by Acinetobacter baumannii (A. baumannii) is an important problem disorder in neurosurgical patients that can lead to serious medical complications, or even to death. This is because A. baumannii frequently can develop multi-drug resistance to several classes of antibiotic, rendering conventional treatment method ineffective. In this case study, we report a case where our patient who is infected with post neurosurgical ventriculitis from A. baumannii (pan-drug resistant strain) is successfully treated with 12 grams per day of intravenous sulbactam concurrent with usual dose of intravenous tigecycline and intraventricular colistin. This successful treatment can be another novel adjunctive therapy for the treatment of CNS infection caused by A. baumannii (pan-drug resistant) using intravenous non-colistin base plus intraventricular colistin base regimen in post neurosurgical condition.

Keywords: Post neurosurgical ventriculitis, multidrug resistant, Acinetobacter baumannii, intraventricular colistin, intravenous high dose sulbactam

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