Povidone-iodine Induced Fixed Bullous Eruption: A Case Report
Published: 2020-08-12
Page: 105-109
Issue: 2020 - Volume 3 [Issue 1]
Zaruhi G. Kalikyan *
Chair of Clinical Immunology and Allergy, Yerevan State Medical University, Yerevan, Armenia.
Sona S. Harutyunyan
Chair of Clinical Immunology and Allergy, Yerevan State Medical University, Yerevan, Armenia.
Tatevik G. Aloyan
Department of Clinical Immunology and Allergy, “Heratsi” N1 University Hospital Complex, Yerevan, Armenia.
*Author to whom correspondence should be addressed.
Abstract
Fixed drug skin eruption to the iodine especially manifesting by bullous lesions is very rare. We present a case of a 73-year-old female who developed multiple blisters on the fingers of both hands with serous or serous-hemorrhagic content after a week of postoperative topical use of Povidone-iodine. Clinically diagnosed bullous eruption resolved in 12 days on the background of offending drug discontinuation and systemic steroid treatment but then it was reappeared at the same site after re-treatment of inflamed wound with the same antiseptic drug. Three months later after the complete resolution of the symptoms, diagnostic examinations such as patch-test and provocation were performed. On the basis of these test results, the diagnosis of a fixed bullous eruption caused by Povidone-iodine was confirmed.
Keywords: Bullous drug eruption, povidone-iodine, patch-test.