The Etiology and Diagnosis of Primary Myelofibrosis: Case Study
Published: 2022-06-17
Page: 35-39
Issue: 2022 - Volume 5 [Issue 1]
M. B. Indu *
Department of General Medicine, ABVIMS and Dr. RMLH, New Delhi, India.
Saima Khan
Department of General Medicine, ABVIMS and Dr. RMLH, New Delhi, India.
Brijesh Sharma
Department of General Medicine, ABVIMS and Dr. RMLH, New Delhi, India.
P. Lalita Jyotsana
Department of Pathology, Lady Hadringe Medical College, New Delhi, India.
*Author to whom correspondence should be addressed.
Abstract
Primary myelofibrosis is a myeloproliferative neoplasm. It is the rarest among the group of myeloproliferative neoplasms and the incidence is 0.1-1 per 1,00,000 per year. This is characterised by the replacement of normal marrow by fibrous tissue. Patients may present with hepatosplenomegaly due to extramedullary erythropoiesis. A high index of suspicion is needed to diagnose the same. This study describes a case that was diagnosed to have myelofibrosis when he presented with splenomegaly as a main symptom.
Keywords: Primary Myelofibrosis, splenomegaly, extramedullary erythropoiesis, myeloproliferative disorder