Stevens-Johnson Syndrome –Toxic Epidermal Necrolysis Induced by Lamotrigine in a 15-Year-Old Girl: A Case Report
Mohamed Benani *
Department of Anesthesiology and Intensive Care, Faculty of Medicine and Pharmacy of Rabat, Military Instruction Hospital Mohammed V, University Mohammed V Souissi Rabat, Morocco.
Yassine El Adraoui
Department of Neurology, Faculty of Medicine and Pharmacy of Rabat, Military Instruction Hospital Mohammed V, University Mohammed V Souissi Rabat, Morocco.
Hamza Najout
Department of Anesthesiology and Intensive Care, Faculty of Medicine and Pharmacy of Rabat, Military Instruction Hospital Mohammed V, University Mohammed V Souissi Rabat, Morocco.
Ayoub Boubekri
Department of Anesthesiology and Intensive Care, Faculty of Medicine and Pharmacy of Rabat, Military Instruction Hospital Mohammed V, University Mohammed V Souissi Rabat, Morocco.
Saad El Harrak
Department of Anesthesiology and Intensive Care, Children's Hospital of Rabat, Faculty of Medicine and Pharmacy of Rabat, University Mohammed V SOUISSI RABAT, Morocco.
Chakib Chouikh
Department of Anesthesiology and Intensive Care, Faculty of Medicine and Pharmacy of Rabat, Military Instruction Hospital Mohammed V, University Mohammed V Souissi Rabat, Morocco.
Hicham Balkhi
Department of Anesthesiology and Intensive Care, Faculty of Medicine and Pharmacy of Rabat, Military Instruction Hospital Mohammed V, University Mohammed V Souissi Rabat, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are immune complex-mediated hypersensitivity reactions and have been associated with numerous adverse drug side effects. TEN and SJS are important adverse drug reaction in dermatology and medicine department. For better patient care and reduce burden to patients effective reporting of ADRS are necessary. Effective reporting also affect on reducing mortality and morbidity. This study is scientifically sound.
Lamotrigine (LTG), an anticonvulsant and mood stabilizer drug, may be associated with this adverse reaction affecting the skin and mucous membranes.
SJS carries high mortality and morbidity and requires special attention as the use of LTG is increasing in clinical practice.
We present a case where the patient developed Stevens-Johnson syndrome at 2 weeks after starting LTG treatment.
The case is discussed because of its relevance to the use of LTG which is commonly prescribed by neurologists and psychiatrists and whose use should be stopped at the appearance of skin-mucous membrane rash.
Keywords: Stevens-Johnson syndrome, toxic epidermal necrolysis, lamotrigine