Asian Journal of Case Reports in Medicine and Health

Exceptional Association of a Common Variable Immunodeficiency and Ankylosing Spondylitis: A Case Report

H. Bellamine *

Internal Medicine Department, CHU Ibn Rochd, Casablanca, Morocco.

M. Moudatir

Internal Medicine Department, CHU Ibn Rochd, Casablanca, Morocco.

K. Echchilali

Internal Medicine Department, CHU Ibn Rochd, Casablanca, Morocco.

L. Barakat

Internal Medicine Department, CHU Ibn Rochd, Casablanca, Morocco.

M. Benzakour

Internal Medicine Department, CHU Ibn Rochd, Casablanca, Morocco.

H. Elkabli

Internal Medicine Department, CHU Ibn Rochd, Casablanca, Morocco.

*Author to whom correspondence should be addressed.

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Abstract

We report a new observation of an unusual association of CVID with ankylosing spondylitis (AS). Osteoarticular involvement associated with CVID occurs in approximately 5 to 40% of cases, most commonly in the form of septic arthritis, or non-septic arthritis, which is part of the joint manifestations of autoimmune and rheumatic diseases associated with CVID. A 53-year-old patient with a history of recurrent bronchopulmonary infections complicated by bronchial dilatation since the age of 38, pelvic-axial syndrome and peripheral inflammatory arthralgia affecting the large and medium-sized joints and enthesitis (talalgia), who has presented since the age of 40 with a digestive disorder consisting of chronic liquid diarrhoea with 6 stools a day, developing in the context of a deterioration in her general condition, without any mention of medication. Regarding biotherapy, in particular anti-TNF alpha, this is the first-line biotherapy for APS. It has been shown to be effective in patients with CVID with joint involvement in the course of granulomatous disease, which would be beneficial for our patient.

Keywords: Ankylosing spondylitis, granulomatous diseases, immunoglobulins, autoimmune manifestations

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