Asian Journal of Case Reports in Medicine and Health

Diabetic Ketoacidosis Revealing Adult Cystic Fibrosis Associated with Graves' Disease: About One Case

Lakrafi Yassir *

Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Barakat Leila

Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Benzakour Merieme

Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Echchilali Khadija

Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Moudatir Mina

Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

Hassan ElKabli

Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.

*Author to whom correspondence should be addressed.

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Abstract

Cystic fibrosis is most often diagnosed in the first years of life due to pancreatic insufficiency and respiratory damage with chronic bronchial suppuration. However, moderate or monosymptomatic forms may only appear in adulthood. As for Graves' disease, it is an autoimmune pathology causing hyperthyroidism, its most characterising manifestation being a homogeneous goiter. It preferentially affects relatively young women, but can occur at any age. The association of cystic fibrosis and Graves' disease is a possibility described in the medical literature and that our case illustrates, this association can be fatal when cystic fibrosis is responsible for diabetes at the insulin deficiency stage and the latter is associated to hyperthyroidism canceling out any effect of insulin treatment, thus endangering its vital prognosis.

Keywords: Diabetic ketoacidosis, cystic fibrosis, genetic disease

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