Diabetic Ketoacidosis Revealing Adult Cystic Fibrosis Associated with Graves' Disease: About One Case
Published: 2024-04-15
Page: 51-57
Issue: 2024 - Volume 7 [Issue 1]
Lakrafi Yassir
*
Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.
Barakat Leila
Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.
Benzakour Merieme
Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.
Echchilali Khadija
Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.
Moudatir Mina
Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.
Hassan ElKabli
Department of Internal Medicine and Geriatrics Unit of the Ibn Rochd University Hospital Center in Casablanca, Morocco and Faculty of Medicine and Pharmacy of Casablanca, Hassan II University, Morocco.
*Author to whom correspondence should be addressed.
Abstract
Cystic fibrosis is most often diagnosed in the first years of life due to pancreatic insufficiency and respiratory damage with chronic bronchial suppuration. However, moderate or monosymptomatic forms may only appear in adulthood. As for Graves' disease, it is an autoimmune pathology causing hyperthyroidism, its most characterising manifestation being a homogeneous goiter. It preferentially affects relatively young women, but can occur at any age. The association of cystic fibrosis and Graves' disease is a possibility described in the medical literature and that our case illustrates, this association can be fatal when cystic fibrosis is responsible for diabetes at the insulin deficiency stage and the latter is associated to hyperthyroidism canceling out any effect of insulin treatment, thus endangering its vital prognosis.
Keywords: Diabetic ketoacidosis, cystic fibrosis, genetic disease