Asian Journal of Case Reports in Medicine and Health

A Beneficial Approach of Management for Delayed Diagnosis of Pemphigus Vulgaris: A Case Report

Praveen Kumar Kulkarni

Internal Medicine, KIMS Hospitals, Secundrabad, Telangana, India.

Anand Kumar Vaggu

Dermatology, KIMS Hospital, Secundrabad, Telangana, India.

Sairam Pachala *

Department of Pharmacy Practice, St. Pauls College of Pharmacy, Hyderabad, Telangana, India.

Priscilla Evangeline

Department of Pharmacy Practice, St. Pauls College of Pharmacy, Hyderabad, Telangana, India.

Anusha Manda

Department of Pharmacy Practice, St. Pauls College of Pharmacy, Hyderabad, Telangana, India.

Nagendra Prasad Gadde

Department of Clinical Pharmacy, KIMS Hospital, Secundrabad, Telangana, India.

C. V. Kiran Kumar Reddy

Department of Clinical Pharmacy, KIMS Hospital, Secundrabad, Telangana, India

Sambit Sahu

Department of Clinical Pharmacy, KIMS Hospital, Secundrabad, Telangana, India.

*Author to whom correspondence should be addressed.

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Abstract

The most typical kind of pemphigus is pemphigus vulgaris, an uncommon chronic skin condition characterized by blisters. Desmosomes, which are skin-related elements that maintain some skin layers bonded to one another, are the target of this type II hypersensitivity reaction, in which antibodies are produced against them. In 2022, A 44-year-old female patient was admitted to the emergency department with complaints of skin lesions with burning sensation and irritation, fever and weakness of limbs. This case report highlights the treatment approach for pemphigus vulgaris during the worsened stage when immediate treatment is not initiated.

Keywords: Acantholysis, desmosomes, hypersensitivity, pemphigus vulgaris

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References

Silva SC, Nasser R, Payne AS, Stoopler ET. Pemphigus Vulgaris. J Emerg Med. 2019;56(1):102–4.

Kianfar N, Dasdar S, Mahmoudi H, Daneshpazhooh M. Burden of pemphigus vulgaris with a particular focus on women: A review. Int J Womens Dermatol. 2022; 8(3):e056.

Loewenthal R, Slomov Y, Gonzalez-Escribano MF, Goldberg I, Korostishevsky M, Brenner S, et al. Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: A study using microsatellite markers. Tissue Antigens. 2004;63(4): 326–34.

Rai A, Arora M, Naikmasur V, Sattur A, Malhotra V. Oral pemphigus vulgaris: case report. Ethiop J Health Sci. 2015; 25(4):637.

Nili A, Salehi Farid A, Asgari M, Tavakolpour S, Mahmoudi H, Daneshpazhooh M. Current status and prospects for the diagnosis of pemphigus vulgaris. Expert Rev Clin Immunol. 2021;17(8):819–34.

Kilic A. Pemphigus: subtypes, clinical features, diagnosis, and treatment. In: autoimmune bullous diseases. In Tech; 2018.

Gregoriou S, Efthymiou O, Stefanaki C, Rigopoulos D. Management of pemphigus vulgaris: challenges and solutions. Clin Cosmet Investig Dermatol. 2015;521.

Zheng J, Liu N, Wang Y, Chen F, Ding Y. Pemphigus vulgaris with psoriasis vulgaris successfully treated with methotrexate and low‐dose methylprednisolone. Dermatol Ther. 2020;33(1).

Joly P, Horvath B, Patsatsi Α, Uzun S, Bech R, Beissert S, et al. Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV). Journal of the European Academy of Dermatology and Venereology. 2020;34(9):1900–13.

Huang YHuei, Kuo CFu, Chen YHua, Yang YWen. Incidence, mortality, and causes of death of patients with pemphigus in Taiwan: A nationwide population- based study. Journal of Investigative Dermatology. 2012;132(1):92–7.