Case Report: Hepatitis-associated Severe Aplastic Anemia of Unknown Etiology
Published: 2022-07-30
Page: 110-116
Issue: 2022 - Volume 5 [Issue 1]
Muditha Jayaweera *
National Hospital of Sri Lanka, Sri Lanka.
Wasantha Kodikaraarachchi
National Hospital of Sri Lanka, Sri Lanka.
Himal Kalambarachchi
National Hospital of Sri Lanka, Sri Lanka.
*Author to whom correspondence should be addressed.
Abstract
Aplastic anemia (AA) is a life-threatening, autoimmune-mediated condition that targets bone marrow precursors leading to pancytopenia. Hepatitis-associated aplastic anemia (HAAA) is one of the rarest entities where the recovery of acute hepatitis is complicated by aplastic anemia. Hepatitis viruses (A-E, G), non-hepatitis viruses (cytomegalovirus, Epstein-Barr virus, HIV, Parvovirus B19, and echoviruses,) and drugs/toxins have been recognized as etiological agents. We present a case of a 29-year-old Asian male presenting with progressive jaundice, diagnosed to have acute cholestatic hepatitis, subsequently leading to severe aplastic anemia without an identified inciting agent.
Keywords: Acute hepatitis, aplastic anemia, hepatitis-associated aplastic anemia, idiopathic